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Tianeptine Pharmaceutical Intermediates
Tianeptine Pharmaceutical Intermediates

Tianeptine Pharmaceutical Intermediates

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Tianeptine


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


CAS:66981-73-5

MF:C21H25ClN2O4S

MW:436.95

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Properties

Melting point:129-131°C

 

Abstract

Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in elderly patients and in those following alcohol withdrawal; such patients can be more sensitive to the adverse effects of psychotropic drugs. Recent interesting results indicate anticonvulsant and analgesic activity of tianeptine and its possible interaction with adenosine A1 receptors.
Tianeptine is neuroprotective via multiple neurochemical and cellular mechanisms. In theory, tianeptine's neuroprotective action makes it a potential life-extension drug. When an organism is under stress, or perceives itself under stress, the hypothalamus secretes corticotropin-releasing hormone/factor (CRH/CRF). CRH/CRF in turn increases secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary.


ACTH in turn stimulates the release of glucocorticoids from the adrenal cortex. Persistent, uncontrolled physical and psychosocial stress causes excess cortisol secretion from the adrenal glands. Excess cortisol causes dendritic shrinkage in the hippocampus and a contrasting growth of dendrites in the lateral amygdala. These stress-induced changes tend to lower mood; they can cause clinical depression in the genetically vulnerable. Current evidence suggests that tianeptine acts to prevent and even reverse stress-induced neural damage, promoting both neuronal survival and synaptic plasticity.

 

Usage And Synthesis
Uses Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant
Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety.[1] Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.

 

Health Effects of Tianeptine

1) Tianeptine Improves Depressive Symptoms

2) Tianeptine Lessens Anxiety, Stress, and PTSD and Symptoms From Stress

3) Tianeptine Benefits Memory and Learning

4) Tianeptine is an Anti-inflammatory

5) Tianeptine Combats Pain

6) Tianeptine Helps Treat Irritable bowel Syndrome

7) Tianeptine Reduces Asthma

 

HOW DOES TIANEPTINE WORK ?
What makes Tianeptine so effective is that it reduces stress on the brain, both physical and mental. Tianeptine causes stress-induced alterations morphology and synaptic plasticity. As it alleviates stress, it also improved learning, brain cognition and memory, two things often diminished by serious depressive conditions. (Zoldaz & et. al, 2010). Like many drugs, there are still studies and concerns that the efficiency and effectiveness of Tianeptine as a whole is difficult to ascertain. After all, Tianeptine, like many drugs, can have a vastly distinct effect on some people and entirely different one on others. More studies are needed to determine if there is a universal dose or regiment that can produce absolute results .

Dosage
The recommended dosage of Tianeptine capsules is usually 12-36 mg per day, taken as 12mg individual dosages, one in the morning and one in the afternoon and a final in the evening time. This substance is sold in capsule, tablet and powder form.

Medical Uses

Depression and Anxiety

Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects.[9] It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.

 

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