Changzhou Kaiqiao Biotechnology Co.,Ltd

Telephone:

+86-180-38176818

Tauroursodiol Ursodeoxycholic Acid Pharmaceutical Intermediates
Tauroursodiol Ursodeoxycholic Acid Pharmaceutical Intermediates

Tauroursodiol Ursodeoxycholic Acid Pharmaceutical Intermediates

Contact : Mr.Thyen-------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Send Inquiry

  • Product Details

Ursodeoxycholic Acid


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


CAS:128-13-2

MF:C24H40O4

MW:392.57

EINECS:204-879-3

Synonyms:Tauroursodiol;Urosodeoxycholic Acid;Ursodeoxycholic acid(micronized);(3a,5b,7b)-3,7-Dihydroxycholan-24-oic acid;7BETA-HYDROXYLITHOCHOLIC ACID;6BETA-CHOLANIC ACID-3A,7BETA-DIOL;(6-BETA)-CHOLANIC ACID-(3-ALPHA)-(7-BETA)-DIOL;3A,7B-DIHYDROXY-5B-CHOLAN-24-OIC ACID

img27718.JPG

Properties

Melting point:203-204 °C(lit.)

alpha 60 º (c=2, EtOH)

refractive index 60.5 ° (C=2, EtOH)

Flash point:9℃

storage temp. Refrigerator

solubility ethanol: 50 mg/mL, clear

form Solution

color Clear colorless

Water Solubility practically insoluble





Description

1. Tauroursodeoxycholic acid is white powder, almost insoluble in water, freely soluble in alcohol
Use: Ursodeoxycholic acid Ursodiol is used for the dissolution of cholesterol gallstones and prevention of drug-induced gallstones. Ursodeoxycholic acid can also be used for the treatment of stearrhea.
2. Tauroursodeoxycholic acid TUDCA 14605-22-2 Ursodiol also known as ursodiol, is a compound produced from bile by the action of intestinal bacteria. Since this bile acid is not produced directly by the body, it is known as a secondary bile acid. One of the functions of bile acids is to act in the intestine to help digest fats and fat-soluble vitamins from food. Ursodeoxycholic acid has been used in pharmacology to dissolve gallstones made of cholesterol, and to treat liver disorders. It has been used for a long time in both human and veterinary medicine.

 

Usage

Used as an anticholelithogenic . Epimer with Chenodiol with respect to the hydroxyl group at C7 Gallstone dissolving drugs. Mainly used in the treatment of inoperable cholesterol gallstones, especially basic gallbladder function properly, stones 15mm or less in diameter, through X-ray, non-calcified cholesterol stones floating high cure rate. Of toxic hepatitis, cholecystitis, primary sclerosing cholangitis, primary biliary cirrhosis of liver also have some therapeutic effect. Improve the efficacy of α- interferon treatment of chronic hepatitis C. Diarrhea, constipation rare, allergic reactions, itching, headache, dizziness, stomach pain, pancreatitis, and bradycardia. Biliary complete obstruction and severe liver dysfunction and pregnant women hanged.

 

Abstract

Ursodeoxycholic acid isolated out a chemical natural bile acid, is the difference between CDCA to stereoisomers, its RONGSHI action, efficacy and chenodeoxycholic acid are similar, but short course small dosage. In vivo binding taurine is present in bile acid is a hydrophilic, as a cholesterol gallstone dissolving agent. Can reduce the secretion of cholesterol the liver, reduce cholesterol saturation of bile, stimulates bile acids increase the solubility of cholesterol in the bile, cholesterol stones dissolve or prevent the formation of stones.

Increase the secretion of bile, bile duct mouth sphincter relaxation produce gallbladder, it is conducive to the stones. This product can not dissolve other types of gallstones. Ursodeoxycholic acid useful in the treatment of cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis and prevention of liver allograft rejection and reaction. RONGSHI effect of this product is slightly weaker than the CDCA.

 

Specification

Item

Specification

Appearance

White or almost white powder

Identification-UDCA

A. Comparable IR absorption with the reference.
B. The spot is similar in position,colour    and size with the reference spot
C. A blue-green precipitate occurs

Melting Point

About 202

Specific optical rotation

+58.0º ~ +62.0º

Heavy Metal

NMT 10ppm

Loss on drying

NMT 1.0%

Sulphated ash

NMT 0.10%

Related substances(TLC )
-Lithocholic acid
-Chenodeoxycholic acid
-Cholic acid
-Any    other single impurity


NMT 0.10%
NMT 1.0%
NMT 0.5%
NMT 0.25%

Assay (C 24 H 40 O 4 )

99.0% ~ 101.0%(as dry basis)



Our Advantages
1. High quality with competitive price
1) Standard:BP/USP
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2. Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3. We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our
responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.

 

Hot Tags: tauroursodiol ursodeoxycholic acid pharmaceutical intermediates, China, suppliers, manufacturers, wholesale, buy, price
Related Products
  • Feedback