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Raloxifene HCl Pharmaceutical Intermediates
Raloxifene HCl Pharmaceutical Intermediates

Raloxifene HCl Pharmaceutical Intermediates

Contact : Mr.Thyen-------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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  • Product Details

Raloxifene Hydrochloride


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


1. Description:

Raloxifene hydrochlorideis an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds. Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4SHCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl is an off-white to pale yellow solid that is very slightly soluble in water.

 

2. Quick details:

Product name: Raloxifene hydrochloride
CAS : 82640-04-8
Molecular Formula: C28H28ClNO4S
Molecular Weight: 473.58328
Melting point: 143-147degree centigrade
Boiling Point: 728.2 degree centigrade at 760 mmHg
Flash Point: 394.2 degree centigrade
Density:1.285 g/cm3
Water solubility:DMSO: 28 mg/mL, soluble
Appearance: Light yellow solid
Indications: This product is mainly used to prevent postmenopausal osteoporosis

Usage of Raloxifene Hydrochloride : Used for the prevention and treatment of postmenopausal osteoporosis, can significantly reduce the incidence of vertebral fractures.

3. Additional Info:

Synonyms:Raloxifene HCl
Assay:99%
Delivery Time:Within 24 Hours After Payment
Shipping:Express Courier(EMS, DHL, UPS, TNT, FedEx)
Export Markets:Global
Trademark:shuangbojie
Packing:Disguised Package or as Required
Origin:China
HS Code:29144000

Storage: Stored in cool and dry place, keep away from strong light /heat.
Shelf Life: 2 years when properly stored.

 

4. Application:

Breast Cancer
Reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis.

Reduction in the incidence of invasive breast cancer in postmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial). Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established.

 

5. Function of Cyproterone:

Used in the treatment of male sexual desire is unusual, women hirsutism, acne, precocious puberty and prostate cancer, etc.

Has function of resistant sexual desire to a variety of sexual perversion (gay, exhibitionism, voyeurism, pedophiles) and heterosexual hypersexuality.

This product and ethinylestradiol compound, can be used as a short-acting oral contraceptives.Also has the obvious curative effect for female acne.

For women Contraception Is a kind of high efficiency, low toxicity and no side effects of a new generation of nonsteroidal pill;

With resistance to salt cortex hormone and antiandrogen role, has a broad market prospect.


6 COA:

Test items

Specification

Test results

Appearance

Yellowish powder

Comply

Identification

Ir

Comply


It meets the requirements of the test for choride

Comply

Solubility

Soluble in 10% sodium hydroxide solution, slightly soluble

in methanol

,insoluble in water

Comply

Assay

98.5%~101.5%

99.15%

Related substances

Rrt=0.74 impurity

≤0.20%

Comply


Other single impurity

≤0.10%

0.07%


Total impurities

≤0.5%

0.26%

Loss on drying

≤0.5%

0.10%

Residue on ignition

≤0.1%

Comply

Heavy metals

≤10ppm

Comply

Storage

Preserve in well-closed containers and protected from light.

Store at room temperature.

Conclusion

Complies with usp32 standard



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