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Pyrroloquinoline Quinone PQQ Pharmaceutical Intermediates
Pyrroloquinoline Quinone PQQ Pharmaceutical Intermediates

Pyrroloquinoline Quinone PQQ Pharmaceutical Intermediates

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Pyrroloquinoline Quinone


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


CAS:72909-34-3

MF:C14H6N2O8

MW:330.21

Synonyms:PQQ Cofactor, Pyrroloquinoline quinone, 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid;Pyrroloquinoline quinone ,98%;Coenzime PQQ;Coenzyme PQQ;Methoxatine;Pyrroloquinoline quinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid;Pyrroloquinoline quinone(PQQ)

Properties

storage temp.

2-8°C

Stability:

Light and Temperature Sensitive

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Background 

It was discovered by J.G. Hauge as the third redox cofactor after nicotinamide and flavin in bacteria (although he hypothesised that it was naphthoquinone). Anthony and Zatman also found the unknown redox cofactor in alcohol dehydrogenase. In 1979, Salisbury and colleague as well as Duine and colleagues extracted this prosthetic group from methanol dehydrogenase of methylotrophs and identified its molecular structure. Adachi and colleagues discovered that PQQ was also found in Acetobacter.


Controversy regarding role as vitamin
The scientific journal Nature published the 2003 paper by Kasahara and Kato that essentially stated that PQQ was a new vitamin and in 2005, an article by Anthony and Fenton that stated that the 2003 Kasahara and Kato paper drew incorrect and unsubstantiated conclusions.

 

Abstract

PQQ (which stands for Pyrroloquinoline quinone) is a B-vitamin-related nutrient that Nature magazine recommended be classified as a new vitamin back in 2003. At the time, The Washington Post ran a headline proclaiming "1st New Vitamin in 55 Years." Of course my interest was piqued and I set out to learn more.

PQQ is found throughout our food supply. Beans, potatoes, parsley, green tea and fermented foods. Interestingly, it's found in high amounts in human breast milk. In the body we find it concentrated in vital organs with high energy requirements, like the brain and the heart, and within red blood cells.PQQ is active within cellular mitochondria, the energy center of the cell. This has major implications for brain health, nervous system health, and potentially other systems, structures and functions throughout the body. This nutrient displays antioxidant activity, neuroprotective action, and cognitive benefits. The breadth of PQQ's influence is nothing short of amazing.

What does this mean for our daily lives? It means Water soluble Pyrroloquinoline quinone may have the power to help protect brain function well into our advanced years. Initial evidence of this was demonstrated in a 2009 study published in the medical journal Food Style.1 In this double-blind, placebo-controlled study, 71 men and women aged 45-65 consumed foods fortified with 20 mg of PQQ (as found in our new maximum potency formula), PQQ plus CoQ10, or placebo, for 12 weeks. Throughout the study, subjects participated in cognitive tests designed to measure memory, recall and cerebral function. The graph shown illustrates the results. Similar results were reported in a 2011 follow-up study in which PQQ was given directly as a supplement.

 

Specification

Analysis Test

Specification

Result

Description

Dark red powder

Conforms

Solubility

Easily soluble in water, unsoluble in ethanol

Conforms

PH

6.0~7.5

6.9

Solution clarity and color

solution should be clear and colorless

Conforms

Related substances

5 ‘MP 0.3%

Simple impurity

Total other impurity

0.01%

0.03%

0.10%

Chloride

0.05%

Conforms

Ammonium

0.05%

Conforms

Fe

0.01%

Conforms

Phosphate

0.1%

Conforms

Loss on drying

≤6.0%

1.3%

Heavy metals

0.002%

Conforms

Arsenide

0.0001%

Conforms

Bacterial Endotoxins

0.3EU/mg

Conforms

Microbial Limit

Conforms

Conforms

Assay(on dried basis)

≥99.0%

99.8%



Main Effect

The purported benefits of pyrroloquinoline quinone supplementation include:

1.An overall improvement in energy levels

2.Improved cognitive function and memory

3.Reduction in mitochondrial degradation

4.Increased skin elasticity

5.Neuro-protectant

6.Cardio-protectant

7.Enhanced nerve growth

 

Application

PQQ protect and promote the generation of new mitochondria, increase cellular energy supply activated cells , skin whitening, skin to repair a variety of skin problems by age . Liver and heart care anti-aging effects .

( One )improve immune function

As an essential factor of human development , can stimulate the growth of human cells , in particular activation of human B cells, T cells , to produce antibodies, improve the body's immune function. PQQ is by far the most potent of human discovery of biologically active substances . NK cells secret !

( Two )liver injury prevention

Can significantly reduce serum bilirubin , alanine aminotransferase levels , to maintain normal liver function , regulating liver damage, liver disease, has an excellent effect.

( Three )reduce free radical damage to human body

PQQ is an oxidoreductase cofactor involved in redox reactions in vivo , can effectively eliminate free radicals , reduce free radical damage to human body , protecting the body tissue, reduce damage to the body caused by various diseases , such as heart disease , cancer and a variety of inflammation. Free radicals are the source of all diseases !

( Four )conditioning various neurological diseases

PQQ is a novel water-soluble vitamins in the body can promote nerve factor synthesis , regulating a variety of neurological disorders .

( Five )to promote the absorption of amino acids

PQQ is a quinone cofactor protease involved in respiratory electron transport chain in the human body through the action of glucose , can promote the absorption of amino acids . Amino acids are composed of cell sap and synthetic peptides of the main raw material, are all important components of biologically active substances .

( Six )can promote the synthesis of growth factors

Growth factor is a human growth hormone that stimulates the growth of organisms that can stimulate the growth of human cells , increasing cell density . PQQ will be able to raise a small amount of biological tissue metabolism and growth function, anti-aging.

( Seven )prevention and treatment of Alzheimer's disease

PQQ specific biological activity and physiological functions is also reflected in the repair of nerve fibers , activation of neurons, activation of dormant nerve cells , can effectively prevent dementia and improve memory , can effectively improve intelligence.


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