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Orlistat Pharmaceutical Intermediates
Orlistat Pharmaceutical Intermediates

Orlistat Pharmaceutical Intermediates

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Orlistat


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Product Name: Orlistat
Synonyms: (-)-Tetrahydrolipstatin(EquivalentToOrlistat);Orlipastat
CAS: 96829-58-2
MF: C29H53NO5
MW: 495.73
Appearance: White crystalline powder
Purity: 99.51%
Standard: USP
Use:An antiobesity agent. A pancreatic lipase inhibitor. Antiobesity agent. Orlistat is an pancreatic lipase inhibitor. Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin is widely used for the treatment of obesity.

 

Orlistat COA:

Items

Standard

Results

Description

White to kind of white powder

kind of white powder

Melting point

193.0-200

196.0-198.9

Water

5-6.5%

5.6%

Solubility

Soluble in methanol

Complies

PH

4.0-6.0

5

Heavy Metals

<10ppm

Complies

Assay

>96%

99.2%

Residue on ignition

<0.1%

0.03%

Single impurity

<0.2%

0.19%

Conclusion

Up to the Standard USP 32.


Orlistat Description:
Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. In most countries, it is sold under the trade name of Roche as a prescription drug and sold by GlaxoSmithKline in the UK and the United States. Its main function is to prevent the intake of fat in the body's diet as a lipase inhibitor, thereby reducing calorie intake. It applies to low-calorie diets that health care providers supervise.

 

Orlistat Application:
The effectiveness of orlistat in promoting weight loss is clear, albeit moderately. The pooled data from clinical trials show that people who give olivide have less than 2-3 kilograms (4.4-6.6 pounds) of medication than a year, except for changes in lifestyle such as diet and exercise. Is also a modest reduction in blood pressure, it seems to be able to prevent the onset of type 2 diabetes, whether due to weight loss itself or other effects; in a large randomized controlled trial, orlistat he was found in obese people will reduce the incidence of diabetes by nearly 40%    Before Taking This Medicine

You should not take orlistat if you are allergic to it, or if you have:

gallbladder problems;

chronic malabsorption syndrome (an inability to absorb food and nutrients properly); or

if you are pregnant.

To make sure orlistat is safe for you, tell your doctor if you have:

liver disease;

kidney disease;

a history of gallstones or kidney stones;

underactive thyroid;

a history of pancreatitis;

type 1 or type 2 diabetes;

an eating disorder (anorexia or bulimia); or

if you take any other weight-loss medications (prescription or over-the-counter).

 

Orlistat Dosage:

1) Usual Adult Dose for Obesity:
120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.
Your daily intake of fat, carbohydrate and protein should be distributed over three meals. This means you will usually take one capsule at breakfast, one at lunch and another at dinner. To gain optimal benefit, avoid the intake of food containing fat between meals, such as biscuits, chocolate and savory snacks.

2) Usual Pediatric Dose for Obesity:
12 years or older:120 mg orally three times a day with each main meal containing fat.
The dose may be taken during the meal or within 1 hour of completing the meal.

 

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