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Melatonin

Melatonin

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Melatonin



Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Applicatin:

1) Melatonin powder is naturally produced in the body in response to the perception of light,

2) Melatonin powder has been used to ease insomnia, combat jet lag, protect cells from free-radical damage, boost the immune system, prevent cancer, and extend life.

 

Specification:

HP90543 73-31-4 Melatonin

Melatonin 73-31-4

73-31-4

Brand: vanz

MF C13H16N2O2

MSDS: Aviable

MW 232.2783

EINECS: 200-797-7

Grade Standard:USP34, BP

Melatonin Application

Melatonin is also known as MEL. Melatonin is naturally produced in the body in response to the perception of light,Melatonin has been used to    ease insomnia, combat jet lag, protect cells from free-radical damage, boost the immune system, prevent cancer, and extend life.


Melatonin is a hormone secreted    by the pineal gland in the brain that helps regulate other hormones and maintains the body's circadian rhythm. The circadian rhythm is an internal 24-hour time-keeping system that plays a critical role in determining when    we fall asleep and when we wake up. Darkness stimulates the production of melatonin while light suppresses its activity.


Function:

1) Melatonin can effectively improve sleep quality
2) Melatonin can improve the functional status of the whole body
3) Melatonin can improve human immunity, prevent depression, Alzheimer's syndrome, cataracts, for the treatment of glaucoma also had a marked effect.
4) Melatonin can increase the body's immune system, auxiliary cancer, enhance physical fitness.
5) Melatonin has strong antioxidant effects

6)Improve sleep dosage (0.1 ~ 0.3 mg), and can shorten the awakening time and sleeping time before sleep, improve sleep quality, sleep wake up significantly reduced, short shallow sleep stage, extending deep sleep stage, in the morning wake up threshold value.Has the strong adjust time difference function

 

ANTI-CANCER:

Due to Mel is easy to enter cells, so as to protect the task of the nucleus DNA.If the DNA damage can lead to cancer.
If have enough Mel in the blood, it is not easy to suffer from cancer.

 

How Does Melatonin Work?

Natural melatonin is a highly lipid soluble hormone produced in the pineal gland in the brain. It is synthesized from the amino acid tryptophan and then released into the blood and cerebrospinal fluid, crossing the blood-brain barrier. It sends messages to the melatonin receptor agonist in the brain and other areas of the body to help control the sleep and wake cycles.

Does melatonin help you sleep? When taken as supplement, the function of melatonin is to mimic the effects of the natural hormone. Drowsiness generally occurs within 30 minutes after taking melatonin. However, taking melatonin right before bed may not be the best strategy for all sleep disorders. Ask your doctor about the best method of dosing melatonin. Melatonin does not work for everyone.

 

Before Taking This Medicine

Do not use melatonin if you are allergic to it.

Before using melatonin, talk to your healthcare provider. You may not be able to use this medication if you have certain medical conditions, such as:

diabetes

depression

a bleeding or blood clotting disorder such as hemophilia

taking a blood thinner like warfarin

high or low blood pressure

epilepsy or other seizure disorder

if you are using any medicine to prevent organ transplant rejection

an autoimmune condition

using other sedatives or tranquilizers

It is not known whether melatonin will harm an unborn baby. Do not use this product without medical advice if you are pregnant.

High doses of this medicine may affect ovulation, making it difficult for you to get pregnant.

It is not known whether melatonin passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

 

Melatonin Dosage

Melatonin is considered an effective treatment for jet lag and can aid sleep during times when you would not normally be awake.

Effective starting doses for jet lagrange from 0.3 to 0.5 mg. One milligram tablets can be cut in half to achieve a 0.5 mg dose if smaller doses are not available for purchase. Lower doses may work for some people, while others may need a higher dose, up to 3 to 5 mg. However, higher doses may be associated with more side effects such as headache, next day grogginess, or vivid dreams.

Always start with the lowest melatonin dose. According to a Cochrane review, doses over 5 mg appear to be no more effective than lower doses. It is important to note that much higher doses are available for sale in the U.S., but these doses may result in excessively high levels of physiologic melatonin.

 

Other Uses for Melatonin

How to Take Melatonin for Sleep (Insomnia):

Dosage: Take melatonin 0.1 mg to 0.5 mg thirty minutes before bedtime. Studies suggest melatonin for sleep may be effective in promoting but not maintaining sleep (early morning awakening).

How to Take Melatonin for Shift-Work Sleep Disorders

Dosage: Take melatonin 1.8 mg to 3 mg thirty minutes prior to the desired onset of daytime sleep; melatonin may NOT lead to improved alertness during the nighttime work shift and may only improve daytime sleep time by about 30 minutes.

How to Take Melatonin for Delayed Sleep Phase Disorder

Delayed sleep phase disorder (DSPD) most often occurs in adolescents, possibly due to reduced melatonin productionand melatonin deficiency at this age. Sleep onset is delayed by 3 to 6 hours compared with conventional bedtimes (10 to 11 pm). DSPD can negatively affect school performance, daily activities, and lead to morning drowsiness which can be dangerous for teen drivers. Any sleep disorder in an adolescent should be evaluated by a physician.

Dosage: Take melatonin 1 mg four to six hours before set bedtime. Once a set bedtime is achieved, use maintenance doses of 0.5 mg melatonin 2 hours before expected sleep onset. Bright light therapy and behavioral management may enhance results. Be aware drowsiness may occur after melatonin dose, so avoid hazardous activities such as driving.

How to Take Melatonin for Non-24-Hour Sleep Wake Disorder (Non-24)

More than 70% of people who are totally blind have Non-24, a circadian rhythm disorder. For people who are totally blind, there are no light cues to help reset the biological clock. The sleep time and wake up time of people who have Non-24-Hour Sleep Wake Disorder shifts a little later every day. Sleep times go in and out of alignment compared to a normal sleep-wake phase. Extra minutes add up each day by day and disrupt the normal wake-sleep pattern.

Use of melatonin in Non-24 is to aid in stimulation to reset the biological clock with one long sleep time at night and one long awake time during the day. However, no large-scale clinical trials of melatonin therapy for Non-24 have been conducted to date.

Dosage: Studies on the blind suggest that 0.5 mg/day melatonin is an effective dose.


COA :

Product Name

Melatonin

Items Tested

Specification

Assay( HPLC )

99.0-102%

Description

White or almost white, crystalline powder or colorless crystals.

Identification

IR & UV

Melting point

116-120 C

Loss on drying

< 0.5%

Residue on ignition

< 0.1%

Related substances

< 0.1%

Heavy metal

< 10 ppm

total viable count

< 3000cfu/g

yeast and moulds

< 300cfg/g

e. coli

Absence/g

salmonella

Absence/25g


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