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Huperzine A Pharmaceutical Intermediates
Huperzine A Pharmaceutical Intermediates

Huperzine A Pharmaceutical Intermediates

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Huperzine A


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


CAS: 120786-18-7

MF: C15H18N2O

MW: 242.32

Synonyms: (+/-)-SELAGINE;[+/-]-SELAGINE;SELAGINE;(+/-)-HUPERAZINE A;HUPERAZINE A;(+/-)-HUPERZINE A;HUPERZINE A;1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one

img28887.jpg

Properties

storage temp. 2-8°C

Abstract

Huperzine A is one of the alkaloids contained in a plant known as Chinese club moss. Other types of club moss are common in the United States, but true Chinese club moss is very hard to find on the U.S. market. It can be grown in Hawaii, but not in any other part of this country. Huperzine A and huperzine B are two of the chemicals that have been separated from Chinese club moss.

 

Main Functions

1. Huperzine A is a kind of reversible inhibitor of acetylcholinesterase, it can improve learning

and memory efficiency;

2.For the treatment of myasthenia gravis, the effective rate up to 99%,and have a certain effect on

age-relatedamnesia and senile dementia.

 

Application

1. For the treatment and improvement of memory dysfunction in elder age, improving memory association function; for the memory deterioration caused by excessive use of the brain, improving work efficiency;
2. For memory function deterioration associated with neurasthenia;
3. For memory deterioration caused by cerebral vascular disorder;
4. For memory improvement of Alzheimer's disease, and it has significant effects on improving and restoring the patient's cognitive ability, memory function and abnormal emotion behaviors;

5. For the treatment of myasthenia gravis;
6. For improvement of disturbance of association, low cognitive function, memory deterioration that associated with schizophrenia;
7. For improvement of memory dysfunction associated with a variety of brain diseases and physical disorders.

 

Specification

Items

Specification

Results

Remark

Identification

Positive

Complies

TLC

Appearance

Fine powder

Complies

Visual

Color

Light Brown to Brown

Complies

Visual

Odor

Characteristic

Complies

Organoleptic

Extraction method

Water&Ethanol

Complies


Solubility

Partly soluble in water

Complies

Visual

Particle size

100% through 80 mesh

Complies

80 Mesh Screen

Huperzine-A

≥1.0%

1.03%

HPLC

Moisture

≤5.0%

4.61%

GB/T 5009.3

Ash

≤5.0%

2.88%

GB/T 5009.4

Heavy Metals (as Pb)

≤10 mg/kg

Complies

GB/T 5009.74

Pb

≤2mg/kg

Complies

GB/T 5009.75

As

≤1mg/kg

Complies

GB/T 5009.76

Total Bacteria

≤10,000CFU/g

Complies

GB/T 4789.2

Yeast & Molds

≤100CFU/g

Complies

GB/T 4789.15

Staphylococcus

Absent

Complies

GB/T 4789.10

Coliform bacteria/E.Coli

Absent

Complies

GB/T 4789.3

Salmonella

Absent

Complies

GB/T 4789.4

Packaging

Net 25.00kg/drum.

Shelf life

24 months when properly stored. Tightly sealed in a clean, cool, dry place. Keep away from strong,    direct light.

Conclusion

Complies with specification


Dosage

For improving memory in young people, Huperzine A can be taken at 100 mg twice a day. It has been used at 50 to 200 mcg twice a day to treat Alzheimer's disease. We suggest that regular users take a break from the drug every few weeks to avoid physical habituation. For example, after taking huperzine A daily for three weeks, consider cycling off of it for one week before resuming regular use.
Huperzine A does not need to be taken with food. It is quickly absorbed into the body and will begin to enhance memory immediately. It has a very long half-life in the body, and a single dose will provide benefits for over 24 hours. The drug has been shown to be quite capable of passing the blood-brain barrier after oral ingestion and quickly accumulates in the cerebrospinal fluid.

 

Side Effects

If you stick to the recommended dosage, Huperzine A is considered to be very safe with low risk of side effects. Some mild bad reactions have occurred resulting in side effects such as nausea, vomiting, appetite suppression, restlessness, headaches, high blood pressure and increased sweating.

 

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