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Epinephrine For Anaphylactic Shock
Epinephrine For Anaphylactic Shock

Epinephrine For Anaphylactic Shock

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Epinephrine


Product name: L(-)-Epinephrine


L(-)-Epinephrine Synonyms: (R) - epinephrine; 1- (3,4-dihydroxyphenyl) -2-aminoethanol; 3,4-dihydroxy -α- (methylaminomethyl) benzyl alcohol; adrenal base ; adrenaline; adrenaline; L-3,4- dihydroxy -alpha - ((methylamino) methyl) benzyl alcohol; L- epinephrine


L(-)-Epinephrine English name: L (-) - Epinephrine


L(-)-Epinephrine Synonyms: (-) - epinephrine [qr]; (R) -4- [1-Hydroxy-2- (methylamino) ethyl] -1,2-benzenediol; (r) -epinephrine [qr]; 1,2- Benzenediol, 4- [1-hydroxy-2- (methylamino) ethyl] -, (R) -; 1,2-Benzenediol, 4- [1-hydroxy-2- (methylamino) ethyl] -, (R) -; 1-1- (3,4-dihydroxyphenyl) -2-methylaminoethanol [qr]; 1-adrenalin [qr]; 1-Adrenaline


L(-)-Epinephrine CAS: 51-43-4



MF: C9H13NO3


Molecular Weight: 183.2


EINECS Number: 200-098-7


melting point:215 ° C (dec.) (Lit.)


Specific rotation:-51.5° (c = 4, 1M HCl, dry sub)


Refractive index :-51.5 ° (C = 4, 1mol / L HCl)


Storage :2-8 ° C


Water solubility: <0.01 g / 100 mL at 18 oC


L(-)-Epinephrine Appearance: white crystalline powder.


L(-)-Epinephrine Solubility: soluble in mineral acids and alkali hydroxide solution, slightly soluble in water, soluble in alcohol, ether, acetone, chloroform. Odorless, bitter taste. Exposed in the air and see the light color gradually deep.


L(-)-Epinephrine Summary: epinephrine (adrenaline, epinephrine, capital abbreviations are: A or E) is the main hormone of the adrenal medulla, the biosynthesis mainly in the medulla chromaffin cells norepinephrine first formed, then further through phenethylamine -N- methyl transferase (phenylethanolamine N-methyl transferase, PNMT) the role of the norepinephrine methylated form of adrenaline.


L(-)-Epinephrine Usage: non-steroidal hormone drugs, also used as a hemostatic Adrenosem intermediates. Mainly used for anaphylactic shock, bronchial asthma and cardiac arrest rescue. The main clinical use of cardiac arrest, bronchial asthma, anaphylactic shock, but also treat hives, hay fever and nasal or gum bleeding.


L(-)-Epinephrine Mechanism: the direct effect of the product on the adrenergic α, β receptors, resulting in rapid and brief strong excitement α and β-type effect on the heart β1- receptors excited, can enhance myocardial contractility, heart rate, cardiac increased oxygen consumption. At the same effect on vascular smooth muscle β2- receptor, blood vessels dilate, reduce peripheral vascular resistance and reduced diastolic blood pressure. Β2- excited receptors in bronchial smooth muscle relaxation, bronchodilation, relieve bronchial spasm; for α- receptor stimulant, the skin, mucosal vascular and visceral small blood vessels.


L(-)-Epinephrine COA


ItemsSpecificationResults

CharactersWhite or greyish-white crystalline odorless solublegreyish-white crystalline

powder,freely soluble in acid water,slightly odorless powder

in alcohol ,practically insoluble in ether.

Identificaion0.10N iodine deep red colorvalidity

Specific rotaionBetween -50.0¡ãand -53.5¡ã-51.0¡ã

Loss on dryingNot more than 2.0%0.5%

Residue on lgnitionNegligibleNegligible

Limit of adrenaloneAt 310 nm not more than 0.200.027

Limit of noreponephrineNot more than 4.0%1.0%

AssayNot less than 97.0% and not more than 102.0%99.9%

Residula solventsMethanol: not more than 3000ppmMethanol:1500ppm

StorageStore in vacuum and protected from light

CONCLUSION:The above product complies with the standard of contract. UPS32

L(-)-Epinephrine Product Tags:L(-)-Epinephrine、51-43-4、L(-)-Epinephrine HCL


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