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Clobetasol Propionate
Clobetasol Propionate

Clobetasol Propionate

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Clobetasol propionate


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


MF:C25H32ClFO5
MW:466.97
CAS:25122-46-7
Appearance:white powder
Purity:99%
Standard:USP standard

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.

 

The COA of Clobetasol propionate:

Product name


Clobetasol propionate

CAS No.


25122-46-7

Outer Packing


1KG/bag

Production date


May.,05, 2018

Shelf life


May.,04, 2021

Standard adopted


USP38

Items of analysis

Specification

Results


Description


White or almost white crystalline powder


Almost white crystalline powder


Solubility


Practically insoluble in water,slightly soluble in benzene and diethyl    ether ,sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane


Complies


Identification (IR)


Complies with the Standard


Complies


Specific Rotation


+98°~+104°


+102.6°


Melting point


about 196℃


193.0℃~195.0℃


Loss on drying


max.2.0%


0.06%


Residue on ignition


max. 0.1%


0.03%


Heavy Metals


max.20ppm


Complies


Single impurity


N.m.t 1.0%


0.14%


Sum impurity


N.m.t 2.5%


0.49%


Organic volatile impurities


meet the ICH requirement


Complies


Assay(HPLC,basisondrying)


98.5%~102.0%


99.5%


THF


Not more than 720ppm


Complies


Methanol


Not more than 3000ppm


Complies


DMF


Not more than 880ppm


Complies


Pyridine


≤ 200ppm


Not more than 200ppm


Complies


Dichloromethane


Not more than 600ppm


Complies


Ethanol


Not more than 5000ppm


Complies


Acetone


Not more than 5000ppm


Complies

Conclusion

Qualified

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