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4-Acetamidophenol Pharmaceutical Intermediates
4-Acetamidophenol Pharmaceutical Intermediates

4-Acetamidophenol Pharmaceutical Intermediates

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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4-Acetamidophenol


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


CAS: 103-90-2
MF: C8H9NO2
MW: 151.16
EINECS: 203-157-5
Chemical Properties White Solid

Usage: Analgesic; antipyretic ,antiinfectant.dispersing agent in liquid scintillation counting
General Description Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about Air &Water Reactions Slightly soluble in water.

 

Paracetamol Description:

Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain. There is poor evidence for fever relief in children. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery. It is typically used either by mouth or rectally but is also available intravenously. Effects last between two and four hours.

Paracetamol is generally safe at recommended doses. Serious skin rashes may rarely occur, and too high a dose can result in liver failure. It appears to be safe during pregnancy and when breastfeeding. In those with liver disease, it may still be used, but in lower doses. Paracetamol is classified as a mild analgesic. It does not have significant anti-inflammatory activity and how it works is not entirely clear.

This product is acetanilide antipyretic analgesics. By inhibiting ring oxidase and selectivity in the hypothalamus of the temperature regulating center, the synthesis of prostaglandins in peripheral vascular expansion, sweating and antipyretic effect, strength of its antipyretic effect similar to aspirin.

 

Applications:

Fever

Paracetamol is used for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 °C (101.3 °F).The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.


Pain

Paracetamol is used for the relief of pain.


Osteoarthritis

The American College of Rheumatology recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss. A 2015 review; however, found it provided only a small benefit in osteoarthritis.

Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the NSAIDs aspirin and ibuprofen, but ibuprofen and paracetamol have similar effects in the treatment of headache. Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint. It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns with bleeding with aspirin.


Low back pain

Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first line treatment for low back pain.However other systematic reviews concluded that evidence for its efficacy is lacking.


Headaches

A joint statement of the German, Austrian, and Swiss headache societies and the German Society of Neurology recommends the use of paracetamol in combination with caffeine as one of several first line therapies for treatment of tension or migraine headache. In the treatment of acute migraine, it is superior to placebo, with 39% of people experiencing pain relief at 1 hour compared to 20% in the control group.


Postoperative pain

Paracetamol, when combined with NSAIDs, may be more effective for treating postoperative pain than either paracetamol alone or NSAIDs alone.


Other

The efficacy of paracetamol when used in combination with weak opioids (such as codeine) improved for approximately 50% of people but increases in the number experiencing side effects. Combination drugs of paracetamol and strong opioids like morphine improve analgesic effect.

The combination of paracetamol with caffeine is superior to paracetamol alone for the treatment of common pain conditions including dental pain, postpartum pain, and headache.


Product advantages:

About powder quality

Our product is powders and liquids, the purity of the powder is 99%, so many customers are satisfied with our quality, they often buy our powders. at the some times, They will sell liquid, yes, brother, they make a lot of money.

 

About liquid quality

Clarity of the liquid is very high, there are many customers think the powder is very complex, so they can directly buy our liquid effect is very good! of course,you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter

 

About Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 4-7 to your product.

 

Our strength :

Genuine Products

Our team consist of Chemical researchers and QC inspection team.Each batch of goods are strictly controlled.We only export Safe and Pure steroids.


Low price

100% factory direct supply comfirms that we have price advantages over peers.


Paracetamol COA

Tests

Standards

Results

Appearance

White or almost white ,crystalline powder.

White,crystalline powder.

Identification

A:IR absorption

Complies

Complies


B:UV absorption

Complies

Complies


C:TLC

Complies

Complies

Melting point

168~172°C

169.0~170.9C

Water

Not more than0.5%

0.08%

Related substance

Impurity(chloroacetanilide)not more than 10 ppm

2ppm


Impurity K(4-aminophenol)not more than 50 ppm

15 ppm


Impurity F(4-nitrophenol)not more than 0.05%

Not detected


any other impurity not more than 0.05%

0.01%


Total of other impurities not more than 0.1%

0.02%

Residue on ignition

Not more than 0.1%

0.05%

Chloride

Not more than 0.014%

Less than 0.014%

Sulfate

Not more than 0.02%

Less than 0.02%

Sulfide

Conforms

Conforms

Heavy metals

Not more than 0.001%

Less than 0.001%

Free p-aminophenol

Not more than 0.005%

Less than 0.005%

Limit of P-chloroacetanilide

Not more than 0.001%

Less than 0.001%

Readily carbonizable substances

Conforms

Conforms

Residual solvents

Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5%

0.08%

Assay(anhydrous basis)

99.0~101.0%

99.6%

Conclusion: Complies with USP34/ BP2011


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