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Aarticaine HCl Tetracaine Procaine
Aarticaine HCl Tetracaine Procaine

Aarticaine HCl Tetracaine Procaine

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

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Aarticaine HCl


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Product Name

Aarticaine hydrochloride

Molecular Formula

C18H29ClN2O

Molecular Weight

320.8354

InChI

InChI=1/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)
18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H

CAS Registry Number

23964-57-0

EINECS

245-957-7

Molecular Structure

img04247.JPG

Boiling point

440.6 C at 760 mmHg

Flash point

220.3 C

Vapour Pressure

5.79E-08mmHg at 25 C

Assay

99%

Appearance

White crystalline powder


Aarticaine Hydrochloride Description:

1.Recently, there has been an interest in the use of Aarticaine hydrochloride as a dental local anesthetic solution. It has been reported that the use of lysine hydrochloride as a localized anesthetic is safe and effective. Anesthesia is due to the use of such local anesthetics in dentistry, especially after giving nerve block injections, rare but undesirable adverse reactions.

2.There is no evidence to support the idea that the use of aspirin has a greater risk of associated Aarticaine hydrochloride than the use of any other local anesthesia. Clinical relevance: The purpose of this paper is to review the relative merits of the potential shortcomings of clenafine hydrochloride. The article will also be intended to update the reader's use of local analgesia in carnitine hydrochloride in dentistry, including pharmacological, efficacy and safety issues (including the risk of nerve sensation) that are commonly associated with the administration of the drug.

 

Aarticaine Hydrochloride Applications:
The use of Aarticaine hydrochloride results in inhibition of neuronal activity. Depression makes the nervous system become allergic, causing anxiety and vibration, leading to mild to severe convulsions. Animal studies have shown that the use of procaine in the brain can increase the level of dopamine and serotonin in the brain. Other problems may vary depending on the individual's tolerance to the procaine dose. Central nervous system excitation can cause tension and dizziness, if excessive coordination may lead to respiratory failure. Procaine may also cause myocardial ischemia leading to cardiac arrest.

Aarticaine hydrochloride can also cause allergic reactions, leading to individual breathing, rash and swelling and other issues. The allergic reaction to procaine is usually not against procaine itself, but its metabolite PABA. Approximately one of about 3,000 people has an atypical form of pseudo-alkaline esterase, which does not require hydrolysis of ester anesthetics such as procaine, resulting in increased levels of narcotics in the blood and increased toxicity.

 

Aarticaine Hydrochloride COA


Product name


Articaine HCl


CAS No.


23964-57-0


Outer Packing


25KG


Production date


2017/05/09


Shelf life


2019/05/04


Standard adopted


EP7


Items of analysis


Specification


Results


Description

A white or almost white crystalline power


A white,crystalline power


Solubility

Freely soluble in water and in alcohol


Complies


Identification


A,B,C,D


Complies


PH


4.2~5.2


4.90


Appearance of solution


≤BY6


Complies


Appearance of solution


Solution should be clear


Complies


Related Substances

Impurity A ≤0.2%;Any other impurity ≤0.1%;Total of other impurities ≤0.5%


Not detected;0.08%;0.26%


Heavy metals


≤5ppm


<5ppm


Loss on drying


<0.5%


0.09%


Resiue on ignition


≤0.1%


0.09%


Organic residues


Complies


Complies

Assay


98.5~101.0%

99.60%

Conclusion


Qualified



Articaine Hydrochloride Dosage

Adults
Dental Anesthesia
Submucosal Injection
Usual dosage range: 20–204 mg.

Recommended Dosages (as articaine hydrochloride 4% with epinephrine 1:100,000) for Dental Anesthesia in Healthy Adults

 

Procedure

Volume of Injection (mL)

Total Dose of Articaine Hydrochloride (mg)

Infiltration

0.5–2.5

20–100

Nerve block

0.5–3.4

20–136

Oral surgery

1–5.1

40–204


Prescribing Limits
Pediatric Patients

 

Dental Anesthesia
Submucosal Injection
Maximum 7 mg/kg (0.175 mL/kg).

 

Adults
Dental Anesthesia
Submucosal Injection
Maximum 7 mg/kg (0.175 mL/kg).

 

Special Populations

Hepatic Impairment
Reduce dosage in patients with hepatic disease.

 

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